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The Health Benefits of Conjugated Linoleic Acid (CLA) for Asthma & Allergy

NCT00876356 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2009-04-06

No results posted yet for this study

Summary

Conjugated linoleic acids (CLA) are naturally occurring free fatty acids derived from the tissues and milk of ruminant animals such as cows. CLA has multiple biological properties including regulation of metabolism and immune processes, including tissue inflammation. Asthma symptoms are caused by irritation and inflammation of the airways. Our hypothesis was that CLA may reduce airway inflammation in asthma and thus reduce asthma symptoms. The aim of this pilot study was to investigate the efficacy and safety of CLA as a dietary supplement in mild asthma. Subjects will be assigned to take CLA dietary supplements or placebo (olive oil) for 12 weeks in addition to their usual asthma treatment. They will be monitored for asthma symptoms, side effects, lung function and blood markers of inflammation.

Conditions

Interventions

DIETARY_SUPPLEMENT

Conjugated Linoleic Acid (CLA)

CLA 4.5g/day in three divided doses p.o. for 12 weeks

DIETARY_SUPPLEMENT

Olive oil

Olive oil 4.5g/day x 12 weeks

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Canadian Lung Association/British Columbia Lung Association

    collaborator UNKNOWN

  • Natural Inc./Cognis GmbH (Dusseldorf, Germany)

    collaborator UNKNOWN

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Delbert Dorscheid, MD, Ph.D · University of British Columbia

  • Ruth MacRedmond, MD, FRCPC · University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-05-31
Primary Completion
2002-05-31
Completion
2004-09-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00876356 on ClinicalTrials.gov