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Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing

NCT00856934 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2009-03-06

Study results available
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Summary

This prospective randomized trial evaluated the impact of autologous keratinocytes suspended in platelet concentrates on healing skin graft donor site wounds. It was hypothesized that the treatment would speed and improve wound healing.

Conditions

  • Skin Graft

Interventions

BIOLOGICAL

Autologous Platelet Rich Plasma

Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.

BIOLOGICAL

Keratinocyte suspension

Autologous keratinocytes isolated from skin biopsy suspended in platelet rich plasma before spraying.

OTHER

Standard dressings

Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Wassim Raffoul, PD, MER · CHUV - CPR

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-06-30
Primary Completion
2006-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00856934 on ClinicalTrials.gov