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Strength Training for Skeletal Muscle Adaptation After Stroke

NCT00827827 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2018-07-09

Study results available
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Summary

Chronically disabled stroke survivors experience accelerated skeletal muscle atrophy and other detrimental changes to muscle and surrounding tissues on the paretic side. This unilateral tissue-level damage contributes to worsening disability and insulin resistance. This VA Merit Award will advance the investigators' understanding of the potential for strength training (ST) to reverse stroke-related muscle abnormalities to improve metabolic health, strength, and function. It will be the first study to thoroughly investigate the effects of ST on muscle atrophy, intramuscular fat, muscle fiber characteristics, capillary density and insulin sensitivity after stroke.

Conditions

Interventions

OTHER

Exercise- Strength Training

3x per week lower-extremity ST lasting approximately 45 minutes to 1 hour.

OTHER

Exercise- Stretching Control

3x per week upper and lower body stretching mixed with active and passive range of motion exercises

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Frederick M Ivey, PhD · Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-04-01
Primary Completion
2013-08-31
Completion
2018-06-06

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00827827 on ClinicalTrials.gov