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Plasma Citrulline Concentration in Tropical Enteropathy

NCT00816842 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2009-01-05

No results posted yet for this study

Summary

Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations. The intestine is thus the only organ that normally releases significant amounts of citrulline into the blood stream. The investigators have designed a study looking at the value of measuring plasma citrulline concentration in patients with tropical enteropathy of mixed HIV status. The focus will be on the ability of the intestine to sustain the individual concerned from a nutritional standpoint. The investigators hypothesise that plasma citrulline concentration is a marker of small bowel absorptive integrity and an appropriate surrogate for HIV related enteropathy.

Conditions

  • Malabsorption Syndromes
  • Granulomatous Enteritis
  • Enteritis
  • HIV Enteropathy
  • Ileal Diseases

Sponsors & Collaborators

  • Azienda Ospedaliero-Universitaria di Parma

    lead OTHER

Principal Investigators

  • Cinzia Papadia, MD · Azienda Ospedaliero-Universitaria di Parma

  • Alastair Forbes, BSc MD FRCP ILTM · University College London Hospitals

  • Antonio Di Sabatino, MD · University of Pavia

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1998-10-31
Primary Completion
2008-05-31
Completion
2008-09-30

Countries

  • Zambia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00816842 on ClinicalTrials.gov