Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease

Summary

RATIONALE: Diagnostic procedures that measure biomarker levels in nipple section and blood samples, may help in the early detection of breast cancer.

PURPOSE: This clinical trial is studying nipple secretion samples in detecting breast cancer in patients and healthy participants undergoing breast cancer screening, breast diagnostic studies, or treatment for benign breast disease.

Conditions

• Breast Cancer

Interventions

GENETIC

protein analysis

protein analysis

GENETIC

protein expression analysis

protein expression analysis

GENETIC

proteomic profiling

proteomic profiling

OTHER

diagnostic laboratory biomarker analysis

Performed one time on study

OTHER

immunohistochemistry staining method

Performed one time on study

OTHER

liquid chromatography

Performed on samples collected one time on study

OTHER

mass spectrometry

Performed on samples collected one time on study

PROCEDURE

fine-needle aspiration

Samples collected one time on study at the appointment for fine-needle aspiration where applicable

PROCEDURE

needle biopsy

Samples collected one time on study at the appointment for needle biopsy where applicable

PROCEDURE

radiomammography

Samples collected one time on study at the appointment for radiomammography where applicable

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• City of Hope Medical Center

  lead OTHER

Principal Investigators

• John Yim, MD · City of Hope Comprehensive Cancer Center

Eligibility

Min Age

18 Years

Max Age

120 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2001-07-31

Primary Completion

2012-09-30

Completion

2012-09-30

Countries

• United States

Study Locations