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Vitamin D AND Glucose Handling Evaluated by Glucose Clamp

NCT00809744 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2011-11-03

No results posted yet for this study

Summary

In this study the investigators want to compare glucose handling (insulin secretion and insulin sensitivity) in 100 persons with low and 50 persons with normal-high levels of vitamin D, using a hyperglycemic clamp technique, were sugar is given intravenously for 3 hours in order to keep the blood sugar level at 10 mmol/L. Those with low vitamin D levels will be randomized to treatment with vitamin D3 (cholecalciferol) 40 000 IU/week or placebo for 6 months before a new clamp is performed.

The study hypothesis is that persons with low vitamin D levels have impaired glucose handling which might be improved by vitamin D supplementation.

Conditions

  • Insulin Sensitivity
  • Intraocular Pressure

Interventions

DRUG

cholecalciferol

capsules, 20 000IU, twice a week, 6 months duration

Sponsors & Collaborators

  • Norwegian Council on Cardiovascular diseases

    collaborator UNKNOWN

  • University Hospital of North Norway

    lead OTHER

Principal Investigators

  • Rolf Jorde, Professor · Medical Dpt, University Hospital of Northern Norway

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2010-12-31
Completion
2010-12-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00809744 on ClinicalTrials.gov