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Comparison Between Thrombolysis and Primary Percutaneous Coronary Intervention (PCI) to Treat ST-Segment Elevation Myocardial Infarction

NCT00806403 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 205

Last updated 2008-12-10

Study results available
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Summary

The main objective is to compare a fibrinolytic strategy with an interventional strategy initiated as early as possible, preferably in the pre-hospital phase, with respect to resolution of ST-segment elevation at 120 minutes after inclusion and Thrombolysis In Myocardial Infarction (TIMI) flow grade evaluated at a mandated coronary angiography 5 to 7 days after inclusion.

Conditions

  • Acute Myocardial Infarction

Interventions

DRUG

reteplase 10+10 U

comparison to primary PCI

PROCEDURE

primary PCI

comparison to thrombolysis

Sponsors & Collaborators

  • Stockholm South General Hospital

    collaborator OTHER

  • Region Örebro County

    collaborator OTHER

  • Norra Alvsborgs Lans Hospital, Trollhattan

    collaborator UNKNOWN

  • Varberg Hospital, Sweden

    collaborator OTHER

  • Sahlgrenska University Hospital

    lead OTHER

Principal Investigators

  • Lars Grip, M.D. PhD · Sahlgren's University Hospital/S

  • Leif Svensson, M.D. PhD · Stockholm South General Hospital

  • Johan Herlitz, M.D. PhD · Sahlgren's University Hospital/S

  • Mikael Dellborg, M.D. PhD · Sahlgren's University Hospital/O

  • Ake Ohlsson, M.D. PhD · Stockholm South General Hospital

  • Mikael Aasa, M.D. · Stockholm South General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-11-30
Primary Completion
2003-06-30
Completion
2004-06-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00806403 on ClinicalTrials.gov