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Observational Study of Cortical Spreading Depression in Human Brain Trauma

NCT00803036 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 165

Last updated 2018-01-31

No results posted yet for this study

Summary

Since the primary damage from traumatic brain injury (TBI) is irreversible, the focus of medical management of TBI is preventing secondary injury that can be life-threatening and worsen patient outcome. Insight into the pathologic mechanisms of secondary injury, which are largely unknown, is required for developing better treatments.

In preliminary studies, the investigators have found that a pathologic brain activity, known as spreading depression, recurs in a large number of TBI patients in the first week after injury. Spreading depressions are short-circuits of brain function that arise spontaneously from an injury and spread repeatedly as waves into neighboring brain tissue. Animal research has shown that spreading depressions can cause secondary injury to the brain.

The primary objective of this observational study is to determine whether the occurrence or severity of spreading depression is related to worse neurologic recovery from TBI. Results from the study will determine whether monitoring of spreading depression should be used as a guide or target for improved medical management of the TBI patient.

Conditions

Sponsors & Collaborators

  • University of Miami

    collaborator OTHER

  • University of Pittsburgh

    collaborator OTHER

  • Virginia Commonwealth University

    collaborator OTHER

  • King's College London

    collaborator OTHER

  • University of Cincinnati

    lead OTHER

Principal Investigators

  • Jed A. Hartings, PhD · University of Cincinnati

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-01-31
Primary Completion
2013-09-30
Completion
2014-09-30

Countries

  • United States
  • United Kingdom

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00803036 on ClinicalTrials.gov