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Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)

NCT00800449 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 133

Last updated 2012-02-14

No results posted yet for this study

Summary

The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.

The Haptoglobin 2 allele is found only in man and is believed to have arisen from the Haptoglobin 1 allele by a partial intragenic duplication. Haptoglobin 2 allele frequency is higher than the Haptoglobin 1 allele. It has been hypothesized that the Haptoglobin 2 allele was spread in man due to its selective advantage against life-threatening infections.

In vitro, only the Haptoglobin 2 allele protein, binds to the streptococcus T antigen, resulting in its aggregation and slowing its growth .

Individuals homozygous for the Haptoglobin 1 allele (1-1 genotype) are more prone to the streptococcal infection than individuals with the Haptoglobin 2 allele(2-1 or 2-2 genotype).

The investigators wish to explore the linkage between Hp phenotype and sepsis in pre-term neonates, considering that in this early stage in life, genetic properties which provide a defense against infectious agents will be of heightened importance.

Conditions

  • Neonatal Sepsis

Sponsors & Collaborators

  • Carmel Medical Center

    collaborator OTHER

  • Technion, Israel Institute of Technology

    collaborator OTHER

  • Irina Kessel

    lead OTHER

Principal Investigators

  • Irena Kessel, MD · Carmel Medical Center

Eligibility

Min Age
24 Weeks
Max Age
35 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-08-31
Primary Completion
2011-03-31
Completion
2011-09-30

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00800449 on ClinicalTrials.gov