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Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation

NCT00780481 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 13

Last updated 2017-07-14

Study results available
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Summary

T-PA release is impaired in obese subjects. In order to have a better mechanistic understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation, Radial Artery Tonometry, and other markers of endothelial function and oxidative stress.

Conditions

Interventions

DRUG

Bradykinin

Intrabrachial - 0, 10, 20, 40 ng/100cc/min over 5 minutes at each dose.

Sponsors & Collaborators

  • Vanderbilt University

    lead OTHER

Principal Investigators

  • James AS Muldowney, MD · Vanderbilt University Medical Center

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-01-31
Primary Completion
2011-01-31
Completion
2011-05-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00780481 on ClinicalTrials.gov