MedTrace Logo

Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC.

NCT00775281 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2010-04-27

No results posted yet for this study

Summary

Interstitial cystitis (IC)/chronic pelvic pain syndrome (CPPS) is a clinical syndrome of pelvic pain and/or urinary urgency/frequency in absence of a specific cause such as bacterial infection or damage to the bladder. The pathogenetic mechanisms of IC/CPPS are as yet undefined and it is largely this lack of knowledge, which precludes a systematic therapeutic approach. Experimental evidence, including results from the animal models of cystitis and the knock-out mice, indicate a participation of tachykinin receptors, especially the NK1R, in neurogenic inflammation, which is considered an important element of the IC complex. However, there is very scant information about the molecular mechanisms of IC in humans, or of the types of receptors, which participate in neurogenic inflammation. Based on our molecular biological know-how and the clinical expertise, we propose to investigate the role of the tachykinin and bradykinin receptors and their signalling partners in CPPS and bladder dysfunction in humans.

Conditions

  • Overactive Bladder
  • Painful Bladder Syndrome
  • Chronic Pelvic Pain Syndrome
  • Cystitis, Interstitial

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-10-31
Primary Completion
2010-04-30
Completion
2010-04-30

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00775281 on ClinicalTrials.gov