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Linkage Analysis in Interstitial Cystitis

NCT00675298 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2017-02-03

No results posted yet for this study

Summary

Urologic pelvic pain syndrome (UCPPS), variably termed painful bladder syndrome/interstitial cystitis (PBS/IC) in females and chronic prostatitis/chronic pelvic pain syndrome in men (CP/CPPS), is a chronic, debilitating clinical syndrome presenting as severe pelvic pain with extreme urinary urgency and frequency in the absence of any known cause. The etiologic mechanisms underlying UCPPS are unknown, but recurrence, risks to siblings of affected individuals, concordance among monozygotic twins, and our own preliminary studies indicate a strong genetic contribution to the cause of UCPPS. The overall goal of this proposal is use novel approaches to understand the basis of UCPPS, to identify candidate genes containing mutations that result in UCPPS and determine how the different encoded proteins of these genes interact with one another in a common biological pathway. Ultimately, understanding how mutations in at least five different genes yield the symptoms of UCPPS should lead to improved diagnosis and possible therapies.

Conditions

  • Prostatitis
  • Cystitis, Interstitial
  • Urinary Bladder, Overactive
  • Chronic Pelvic Pain Syndrome
  • Painful Bladder Syndrome

Sponsors & Collaborators

Principal Investigators

  • Jordan D Dimitrakoff, MD, PhD · Beth Israel Deaconess Medical Center

Eligibility

Min Age
3 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-31
Primary Completion
2011-06-30
Completion
2011-06-30

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00675298 on ClinicalTrials.gov