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Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation

NCT00774449 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 261

Last updated 2011-07-21

No results posted yet for this study

Summary

Chronic organ dysfunction after lung transplantation (BOS) is the most common cause of death in long-term survivors after lung transplantation and refractory to most interventions. Early markers will be established in this project study to overcome the problem of disease recognition when impairment of graft function is already taken place. Long-term longitudinal monitoring in stable recipients of innovative markers of airway inflammation and ventilation and new imaging techniques will define different entities of chronic organ dysfunction after LTx. A database and specimen service unit for further projects will be created.

Hypothesis: This project will reveal new markers and imaging tools in recipients who develop BOS after lung transplantation. These tools will allow earlier diagnosis and more accurate monitoring of the disease process. Different patterns of the disease will be characterized.

Conditions

  • Lung Transplantation
  • Bronchiolitis Obliterans Syndrome

Sponsors & Collaborators

  • Hannover Medical School

    lead OTHER

Principal Investigators

  • Jens Gottlieb, MD · Hannover Medical School

Eligibility

Min Age
18 Years
Max Age
68 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2014-06-30
Completion
2014-06-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00774449 on ClinicalTrials.gov