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Metabolomic Study in Exhaled Breath Condensate of Thoracic Surgical Patients

NCT02583984 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2016-05-25

No results posted yet for this study

Summary

Acute lung injury (ALI) following thoracic surgery remains a major source of morbidity and mortality after lung resection. One-lung ventilation (OLV) is usually required in thoracic surgery. OLV is also an important predictor of postoperative ALI. Recent laboratory findings suggested that tissue hypoxemia and ischemia / reperfusion injury of the collapsed lungs during OLV is the major cause of lung injury. Exhaled Breath Condensate (EBC), which is the exhalate from breath typically collected by cooling device, contains most molecules found in the airway. Metabolomics refers to systematic and scientific study of chemical processes involving metabolites. This study will collect EBC for metabolomic analysis and aim to elucidate the biochemical reactions during one-lung ventilation and pathological mechanisms of acute lung injury following thoracic surgery.

Conditions

  • Acute Pulmonary Insufficiency Following Thoracic Surgery
  • Ventilator-associated Lung Injury

Interventions

PROCEDURE

Thoracic Surgery with Lung Resection

General anesthesia and lung separation Thoracic surgery with lung resection, such as lobectomy, segmentectomy

PROCEDURE

Thoracic Surgery without Lung Resection

General anesthesia and lung separation Thoracic surgery without lung resection, such as esophageal surgery, mediastinal surgery

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Principal Investigators

  • Ya-Jung Cheng, MD, PhD · National Taiwan University Hospital

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-03-31
Primary Completion
2018-03-31
Completion
2018-03-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02583984 on ClinicalTrials.gov