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Establishment of a Lifetime of Cohort of Adults Surviving Childhood Cancer

NCT00760656 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10000

Last updated 2026-04-23

No results posted yet for this study

Summary

Childhood cancer predisposes to health risks that may not become apparent until many years after completion of therapy. The SJLIFE protocol is designed to establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital to facilitate evaluation of health outcomes in aging adults surviving pediatric cancer.

The study focuses on the following Primary and secondary objectives:

* To establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital to facilitate evaluation of health outcomes in aging children and adults surviving pediatric cancer.
* To estimate the prevalence, cumulative incidence, and latency of selected late treatment complications following predisposing therapeutic exposures in children and adults surviving pediatric cancer.
* To identify treatment, demographic, and psychosocial / behavioral related predictors of adverse health outcomes.
* To develop risk profiles for adverse health outcomes across the age spectrum to guide development of clinical screening guidelines and risk-reducing interventions.
* To identify factors that may be protective against the development of specific late treatment complications.
* To generate data for a series of future hypothesis-driven trials
* To serve as a source for the collection of samples from child and adult volunteers for future SJLIFE research.
* To collect health outcomes data on a community control population for comparison purposes.
* Characterize longitudinal social determinants of health (SDOH) to examine how living conditions, social integration, and structural inequality interact with personal social integrations/support to influence health.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Melissa Hudson, MD · St. Jude Children's Research Hospital

Eligibility

Min Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-09-13
Primary Completion
2035-12-31
Completion
2035-12-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00760656 on ClinicalTrials.gov