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Dopamine in Orthostatic Tolerance

NCT00748228 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2015-06-15

No results posted yet for this study

Summary

One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will also study whether increasing dietary salt improves symptoms during upright posture. Finally, we will examine whether the dietary sodium level influences serum DBH activity and whether DBH level influences the response to sodium. DBH levels and the function of the sympathetic or involuntary nervous system will be assessed in normal volunteers and in patients with postural tachycardia syndrome (POTS).

Conditions

  • Postural Tachycardia Syndrome

Interventions

DIETARY_SUPPLEMENT

dietary sodium

10 mEq/day

DIETARY_SUPPLEMENT

dietary sodium

300 mEq/day

DIETARY_SUPPLEMENT

dietary sodium

150 mEq/day dietary sodium

Sponsors & Collaborators

  • Vanderbilt University

    lead OTHER

Principal Investigators

  • Emily M Garland, PhD · Vanderbilt University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-11-30
Primary Completion
2012-07-31
Completion
2012-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00748228 on ClinicalTrials.gov