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Postpartum Depression: Transdermal Estradiol Versus Sertraline

NCT00744328 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 85

Last updated 2019-09-10

Study results available
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Summary

The purpose of this study is to determine whether estrogen patches are effective for the treatment of postpartum major depression, as compared to sertraline (Zoloft) and placebo.

Conditions

Interventions

DRUG

Transdermal Estradiol

Estradiol patch ranging in dose from 50 to 200 mcg/day

DRUG

Sertraline

Sertraline dose will range from 50 - 200 mg/day

OTHER

Placebo

Placebo patches and pills that are identical to transdermal estradiol and oral sertraline, respectively, will be used.

Sponsors & Collaborators

Principal Investigators

  • Katherine L Wisner, MD, MS · Northwestern University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-08-31
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00744328 on ClinicalTrials.gov