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Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease

NCT00734266 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2013-03-06

No results posted yet for this study

Summary

The hypotheses of this study are that:

* Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans;
* The increase in these leukotrienes levels after heart surgery is higher in patients with bronchitis and/or emphysema than in patients without previous history of lung disease;
* Levels of leukotrienes are directly correlated with worsening of lung function during and after heart surgery.

Conditions

  • Lung Dysfunction
  • Inflammatory Response During Cardiac Surgery

Sponsors & Collaborators

Principal Investigators

  • Marcos F Vidal Melo, MD · Massachusetts General Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-04-30
Primary Completion
2010-12-31
Completion
2010-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00734266 on ClinicalTrials.gov