Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)

Summary

In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.

In this age bracket, the single randomized which compared endovascular coiling to microsurgical clipping (ISAT Study) showed that the relative risk of morbidity increased after coiling. Moreover, some prospectives studies about endovascular coiling described favorable outcome in 48% to 63% of patients, complete occlusion in 51% to 69% and a procedural complication rate in 13% to 19%. From prospectives series, the proportion of favorable outcome after microsurgical clipping was estimated around 66% but the procedural complications are few reported. The outcome for patients treated conservatively was catastrophic. Lastly, the hydrocephalus in this age class is common, occurring in 55% of patients.

The study hypothesis is that, in this age class, no difference exists between the 2 obliteration procedures.

An accurate evaluation of result in term of functional disability, quality of life and prognosis predictive factors seems a judicious question.

Conditions

• Aneurysmal Subarachnoid Hemorrhage
• Hydrocephalus
• Cerebral Vasospasm

Sponsors & Collaborators

• University Hospital, Rouen

  lead OTHER

Principal Investigators

• François PROUST, M.D., Ph.D. · University Hospital, Rouen

• Serge BRACARD, M.D., Ph.D. · Central Hospital, Nancy, France

• Guillaume PENCHET, M.D. · University Hospital, Bordeaux

• Evelyne EMERY, M.D. · University Hospital, Caen

• Bernard IRTHUM, M.D. · Clermont University Hospital

• Klaus MOURIER, M.D. · Centre Hospitalier Universitaire Dijon

• Emmanuel GAY, M.D. · University Hospital, Grenoble

• Jean-Paul LEJEUNE, M.D. · Lille University Hospital

• Isabelle PELISSOU, M.D. · Hospices Civils de Lyon

• Pierre Hughes ROCHE, M.D. · University Hospital, Marseille

• Thierry CIVIT, M.D. · Central Hospital, Nancy, France

• Michel LONJON, M.D. · Nice University Hospital

• Philippe DAVID, M.D. · Paris University Hospital

• Benoit BATAILLE, M.D. · Poitiers University Hospital

• Xavier MORANDI, M.D. · Rennes University Hospital

• Jacques LAGUARRIGUE, M.D. · University Hospital, Toulouse

• Romain BILLON-GRAND, M.D. · Besançon University Hospital

• Damien BRESSON, M.D. · Paris University Hospital

Eligibility

Min Age

70 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2008-10-31

Primary Completion

2014-01-31

Completion

2014-01-31

Countries

• France

Study Locations