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Understanding Sleep Problems in Children With Autism Spectrum Disorder

NCT00691080 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 58

Last updated 2016-01-13

No results posted yet for this study

Summary

The investigators will examine whether sleep problems in children with autism spectrum disorder (ASD) are related to alterations in the production of melatonin (MT), a hormone that plays an important role in regulating sleep-wake cycle. Children with ASD experience high rates of sleep disturbances that potentially contribute to problems with thinking and behavior. It is unclear if changes in MT production cause sleep problems in children with ASD. MT is frequently used to treat these sleep problems; however, it has not been well established whether MT is an effective treatment. Our hypotheses concerning MT is children with ASD and sleep problems will have a delayed sleep-wake cycle and/or decreased MT production. This study will compare children diagnosed with ASD to "healthy" control children with no ASD diagnosis. All subjects will be recruited from one of three sites: Baylor College of Medicine, Oregon Health \& Science University and Columbia University. The investigators will use a standardized questionnaire to determine whether the child has sleep problems. The investigators will measure MT levels in saliva in ASD children with sleep problems and in a group of control children without sleep problems. Total 24-hour MT production will be determined from urine samples in these same two groups.

Conditions

  • Sleep Problems

Sponsors & Collaborators

  • Autism Speaks

    collaborator OTHER

  • Oregon Health and Science University

    collaborator OTHER

  • Columbia University

    collaborator OTHER

  • The Emmes Company, LLC

    collaborator INDUSTRY

  • Autism Treatment Network

    collaborator NETWORK

  • Baylor College of Medicine

    lead OTHER

Principal Investigators

  • Daniel G Glaze, M.D. · Baylor College of Medicine

Eligibility

Min Age
4 Years
Max Age
9 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-09-30
Primary Completion
2011-09-30
Completion
2011-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00691080 on ClinicalTrials.gov