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The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause

NCT03631680 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 2

Last updated 2022-11-16

No results posted yet for this study

Summary

The overarching aim of this study is to assess the downstream effects of abrupt estrogen deficiency in women undergoing elective bilateral oophorectomy by studying:

1. the rate of in vivo adipogenesis in the subcutaneous abdominal (scABD) and subcutaneous femoral (scFEM) adipose tissue depots following bilateral oophorectomy surgery using an innovative (and tested) 8-week incorporation of stable isotope (deuterium; 2H) administered in the form of heavy water (2H2O) to endogenously label adipose tissue DNA;
2. the changes in expression of subcutaneous adipose tissue genes and proteins specific to adipocyte expansion and function; extracellular matrix remodeling and fibrosis; and inflammation in the scABD and scFEM depots before and after elective bilateral oophorectomy.

Conditions

  • Menopause Surgical
  • Estrogen Deficiency
  • Adiposity

Interventions

PROCEDURE

Bilateral Oophorectomy Surgery

Women undergoing elective, laparoscopic bilateral oophorectomy surgery will be enrolled.

Sponsors & Collaborators

  • Louisiana Clinical and Translational Science Center

    collaborator OTHER

  • Pennington Biomedical Research Center

    lead OTHER

Principal Investigators

  • Kara L Marlatt, PhD, MPH · Pennington Biomedical Research Center

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-25
Primary Completion
2022-11-11
Completion
2022-11-11

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03631680 on ClinicalTrials.gov