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Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

NCT00682357 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2024-08-13

Study results available
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Summary

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis.

Conditions

Interventions

DRUG

Methylprednisolone and Lidocaine

Methylprednisolone 80 mg, intra-articular and lidocaine 20 mg

DRUG

Methylprednisolone and Lidocaine

Methylprednisolone 16 mg intra-articular and lidocaine 20 mg

DRUG

Placebo and Lidocaine

Placebo and lidocaine 20 mg

Sponsors & Collaborators

  • University of Kansas Medical Center

    lead OTHER

Principal Investigators

  • Herbert Lindsley, MD · University of Kansas Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2009-11-30
Completion
2010-05-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00682357 on ClinicalTrials.gov