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Periodontal Infection and Endothelial Dysfunction

NCT00681564 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 102

Last updated 2014-04-17

Study results available
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Summary

The purpose of this study is to determine the effect of periodontal therapy on endothelial function and other biomarkers of cardiovascular disease

Conditions

  • Periodontitis

Interventions

PROCEDURE

One-Stage Full-Mouth Disinfection

* Scaling and root planing, four quadrants in one session * Tongue brushing with a 1% chlorhexidine gel (1 minute) * Mouth rinsing with a 0.2% chlorhexidine solution for (2 minutes) * Subgingival chlorhexidine (1%) irrigation in all pockets * Twice daily rinsing with clorhexidine (1 minute) during fourteen days after the periodontal intervention * Basic oral hygiene instructions * Dental extractions will be performed at the end of patient followup (only in cases of teeth that could not be saved)

PROCEDURE

Periodontal care

* Basic oral hygiene instructions * Supragingival plaque removal

Sponsors & Collaborators

  • Universidad del Valle, Colombia

    lead OTHER

Principal Investigators

  • Adolfo Contreras, DDS, MS, PhD · Universidad del Valle

  • Jorge H Ramirez, MD, MS · Universidad del Valle

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2011-03-31
Completion
2012-01-31

Countries

  • Colombia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00681564 on ClinicalTrials.gov