Effect of Intensive Periodontal Therapy on Vascular Function

Summary

The hypothesis of the existence of a causal association between the systemic infectious/inflammatory burden represented by periodontitis and endothelial function assessed by flow mediated dilatation of the brachial artery (FMD) is the subject of the proposed investigation.

The objective of this randomized controlled clinical trial is to evaluate the effects of periodontal therapy on endothelial function assessed by Flow mediated dilatation (FMD).

The rationale for this project is twofold:

* Establish the extent of acute systemic inflammation and endothelial dysfunction associated with the delivery of subgingival instrumentation for the treatment of chronic periodontitis
* Establish whether or not improved control of chronic periodontal infections results in improved endothelial function and thus the existence of a causal association between periodontitis and endothelial dysfunction.

Conditions

• Periodontitis

Interventions

PROCEDURE

Intensive periodontal therapy

PROCEDURE

Community based periodontal therapy

Sponsors & Collaborators

• University College London Hospitals

  collaborator OTHER

• British Heart Foundation

  collaborator OTHER

• The European Research Group on Periodontology (ERGOPerio)

  collaborator NETWORK

• Johnson & Johnson

  collaborator INDUSTRY

• CORDA, The Heart Charity

  collaborator OTHER

• European Social Fund

  collaborator OTHER

• Italian Society of Periodontology

  collaborator UNKNOWN

• Eastman Dental Insitute and Hospital

  lead OTHER

Principal Investigators

• Maurizio Tonetti, DMD PhD · University College London Hospitals and University of Connecticut Health Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2003-09-30

Completion

2005-03-31

Countries

• United Kingdom

Study Locations