Assessment of Mechanisms of Improved Wound Healing

Summary

The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.

Conditions

• Burns

Interventions

PROCEDURE

Stable Isotope Infusion study

Stable isotope infusion study to be done following each surgery. Tagged isotopes to assess uptake into blood and tissues. Includes collection of blood and tissues (muscle)

DRUG

Insulin High Dose

Insulin IV administered continuously throughout hospitalization until wounds are 95% healed.

DRUG

oxandrolone

Oxandrolone given daily throughout hospitalization until 95% wound healing.

DRUG

Propranolol

Propranolol to be given daily throughout hospitalization until 95% wound healing.

DRUG

Growth Hormone

Recombinant Human Growth hormone to be administered daily until 95% wound healing.

DRUG

Insulin Low Dose

Insulin administered IV until 95% wound healing

DRUG

IGF-1/IGFBP-3

Insulin Like Growth Factor-1/Insulin like Growth Factor Binding Protein 3 administered until 95% wound healing

DRUG

Itraconazole

Itraconazole administered until 95% wound healing

DRUG

Growth Hormone and Propranolol

Growth Hormone and Propranolol given until 95% wound healing

DRUG

Oxandrolone and Propranolol

Oxandrolone and Propranolol

DRUG

Placebo or Control

Administration of Placebo or Control until 95% wound healing

Sponsors & Collaborators

• National Institute of General Medical Sciences (NIGMS)

  collaborator NIH

• The University of Texas Medical Branch, Galveston

  lead OTHER

Principal Investigators

• David N. Herndon, MD · University of Texas

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2000-07-31

Primary Completion

2011-04-30

Completion

2013-04-30

Countries

• United States

Study Locations