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Heritability of Opioid Effects: A Twin Study

NCT00672438 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 242

Last updated 2017-01-06

Study results available
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Summary

Proposed twin study will test to what degree inter-individual differences in pain sensitivity and amount of pain relief in response to opioid therapy are inherited or alternatively, are due to environmental factors. This knowledge is important to guide future studies trying to explain such inter-individual differences. For example, finding that differences are largely due to environmental factors would discourage genomic studies and emphasize epidemiological studies.

Conditions

Interventions

DRUG

Alfentanil

Target controlled intravenous infusion of alfentanil at a plasma concentration of 100ng/ml

OTHER

Saline placebo infusion

Intravenous infusion of normal saline

Sponsors & Collaborators

  • SRI International

    collaborator INDUSTRY

  • Martin Angst

    lead OTHER

Principal Investigators

  • Martin S Angst · Stanford University

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2010-06-30
Completion
2010-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00672438 on ClinicalTrials.gov