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Coronary Bypass and Artotic Leaflet Surgery : Heparin Low Dose vs Full Dose

NCT00657475 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 238

Last updated 2026-05-19

No results posted yet for this study

Summary

The purpose of this study is to demonstrate superiority on postoperative bleeding from the use of a heparin half dose compared to a conventional dose, under mini-extra corporeal circulation, without increased risk to the patient.

Conditions

  • Cardiac Surgery
  • Extracorporeal Circulation

Interventions

DRUG

Heparin Low Dose

Loading heparin dose of 150 IU / kg to achieve an ACT (activating clotting time) target more than 240 seconds.

DRUG

Heparin Full Dose

Loading heparin dose of 300 IU / kg to achieve an ACT (activating clotting time) target more than 400 seconds.

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Xavier ROQUES, PhD · University Hospital, Bordeaux

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-06-30
Primary Completion
2013-02-28
Completion
2013-03-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00657475 on ClinicalTrials.gov