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Role of Proteomics in Diagnosing Sarcoidosis

NCT00626938 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2012-11-07

No results posted yet for this study

Summary

Sarcoidosis is a multi-systemic disorder, meaning that it can involve any organ in the body and that its clinical presentation is highly variable. In 90% of all sarcoidosis cases the lungs are affected. It is difficult to give a concise definition of sarcoidosis due to the fact that its exact cause is still unknown. Consequently, diagnosing the disease is also rather difficult. Up till now, sarcoidosis is generally diagnosed by using general clinical methods to evaluate the status of the lung including a chest X-ray, lung biopsy and bronchoalveolar lavage (BAL). However, some of these methods are considered to be rather invasive and, even more important, non-conclusive. Therefore, the current study has been designed to evaluate the use of a new technique, called SELDI-TOF mass spectrophotometry, for the diagnosis of sarcoidosis. This technique enables the analysis of all enzymes present in the blood of sarcoidosis patients which may hopefully lead to creating a disease-specific protein-profile that may facilitate the recognition of sarcoidosis. Moreover, these results will be compared with other currently used laboratory parameters.

Conditions

  • Sarcoidosis

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Marjolein Drent, Prof,MD,PhD · University Hospital Maastricht, Departement of Respiratory Medicine

  • Otto Bekers, PhD · University Hospital Maastricht, Departement of Clinical Chemistry

  • Christine Voorter, PhD · University Hospital Maastricht, Departement of Tissue Typing

  • Marja P van Dieijen-Visser, Prof,MSc,PhD · University Hospital Maastricht, Departement of Clinical Chemistry

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-03-31
Primary Completion
2012-03-31
Completion
2012-03-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00626938 on ClinicalTrials.gov