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Are Mast Cells Involved in Autoinflammatory Diseases

NCT05292768 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 590

Last updated 2022-03-23

No results posted yet for this study

Summary

Autoinflammatory diseases (AID) are caused by innate immunity dysregulation. AID pathophysiology is only partly understood, especially in the case of unclassified AID. Mast cells (MC) are innate immune cells associated with a spectrum of disease between systemic mastocytosis and mast cell activation syndrome. The implication of MC has been shown in cryopyrin associated periodic syndrome (CAPS).Our aim is to evaluate the involvement of MC in AID by assessing clinical and biological signs of MC activation and studying cutaneous and digestive biopsies.

Conditions

  • Autoinflammatory Disease
  • FMF
  • TRAPS
  • MKD
  • Cryopyrin Associated Periodic Syndrome
  • Haploinsufficiency

Sponsors & Collaborators

  • Institut Imagine

    collaborator UNKNOWN

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Sophie GEORGIN-LAVIALLE, PU-PH · Assistance Publique - Hôpitaux de Paris

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-31
Primary Completion
2026-10-31
Completion
2026-10-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05292768 on ClinicalTrials.gov