Neurobiology and Treatment of Reading Disability in NF-1

Summary

The goal of this trial is to determine if children with neurofibromatosis type 1 who have reading disabilities respond the same way-both behaviorally and neurobiologically-to specialized treatment programs as children with idiopathic reading disabilities do, and to determine which intervention is best for particular learner profiles.

Conditions

• Neurofibromatosis Type 1
• Reading Disabilities

Interventions

BEHAVIORAL

Tutoring Program I

Tutoring Program I is a structured multi-sensory program that is designed to gradually present the range of sounds and letters with focus on accuracy of phonological concepts and application of those concepts in phrases and sentences. The instruction uses a sequenced defined lesson plan with accuracy and automaticity criteria for skill progression. A range of manipulative and kinesthetic activities is outlined to maintain learner engagement in the intensive intervention design.

BEHAVIORAL

Tutoring Program II

Tutoring Program II is designed to teach visual and speech elements of reading separately at first, and then bring them together for maximum efficiency. The program uses the idea of teaching concepts about the structure of words. For example, students transfer the rules they have learned about one vowel or structure to another without specific instructions on the new one. Tutoring Program II incorporates pictures and activities to help remember strategies for increasing basic reading skills. Speed drills are also used for development of decoding automaticity.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS)

  collaborator NIH

• Vanderbilt University

  lead OTHER

Principal Investigators

• Laurie E. Cutting, Ph.D. · Vanderbilt University Special Education Department

• Martha Bridge Denckla, M.D. · Kennedy Krieger Institute, Johns Hopkins University, Johns Hopkins University School of Medicine

• Sheryl L. Rimrodt, M.D. · Vanderbilt University Pediatrics Department

• John Gore, Ph.D. · Vanderbilt University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

8 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2006-02-28

Primary Completion

2013-03-31

Completion

2017-01-31

Countries

• United States

Study Locations