The Early Recognition of Pulmonary Arterial Hypertension

NCT00609349 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2012-01-12

No results posted yet for this study

Summary

The early detection of pulmonary arterial hypertension may help to improve prognosis of the disease. It is assumed that in the early stages of pulmonary arterial hypertension, pulmonary arterial pressure values may be normal at rest, but the remodelling of small arteries leads to stiffening resulting in increased pulmonary arterial pressure during exercise. In the present study we investigate patients with risk factors for pulmonary arterial hypertension (e.g. connective tissue disease) by combining exercise tricuspid echo doppler and cardiopulmonary exercise test to screen patients for exercise-induced pulmonary hypertension and control the results by the gold standard right heart catheterisation at rest and during exercise. We expect that using this screening method, patients with pulmonary arterial hypertension would be recognized earlier.

Conditions

Pulmonary Arterial Hypertension

Interventions

DEVICE

ETED, CPET, RHC

exercise tricuspid echo doppler (ETED): allows the estimation of systolic pulmonary arterial pressure at exercise cardiopulmonary exercise test (CPET) allows to measures exercise capacity (peakVO2) right heart catheterisation (RHC): is the gold standard for the measurement of pulmonary arterial pressure values

Sponsors & Collaborators

Medical University of Graz
lead OTHER

Principal Investigators

Horst Olschewski, MD · Medical University of Graz

Study Design

Allocation: NA
Purpose: SCREENING
Masking: NONE
Model: SINGLE_GROUP

Eligibility

Sex: ALL
Healthy Volunteers: Yes

Timeline & Regulatory

Start: 2006-04-30
Primary Completion: 2009-05-31
Completion: 2009-05-31

Countries

Austria

Study Locations

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Entities

Diseases

Pulmonary Arterial Hypertension