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Assessment of Blood Coagulation Disorders in Patients With Pulmonary Hypertension

NCT03195543 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2019-03-25

No results posted yet for this study

Summary

The objective of the present study is to assess blood coagulation disorders in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. The investigators aim to evaluate any possible coagulation abnormalities related to the patients' primary disease and any possible effects the pulmonary hypertension- specific therapy may have on hemostasis.

Conditions

  • Pulmonary Artery Hypertension
  • Chronic Thromboembolic Pulmonary Hypertension

Interventions

DIAGNOSTIC_TEST

Platelet function analyzer-100

The PFA-100 system evaluates primary hemostasis in whole blood samples.

DIAGNOSTIC_TEST

Light transmission aggregometry

Light transmission aggregometry is the gold standard method for assessing platelet function.

DIAGNOSTIC_TEST

Rotational thromboelastometry

ROTEM is a viscoelastic method for hemostasis testing in whole blood.This assay investigates the interaction of blood cells, coagulation factors and their inhibitors during clotting and subsequent fibrinolysis.

DIAGNOSTIC_TEST

Endogenous thrombin potential

The endogenous thrombin potential assesses the amount of thrombin which can be generated after the in vitro activation of coagulation and represents the balance between pro- and anti-coagulant forces in plasma.

Sponsors & Collaborators

  • National and Kapodistrian University of Athens

    lead OTHER

Principal Investigators

  • Eleni Vrigkou, MD, MSc · National and Kapodistrian University of Athens

  • Argyrios Tsantes, MD, PhD · National and Kapodistrian University of Athens

  • Iraklis Tsagkaris, MD, PhD · National and Kapodistrian University of Athens

  • Apostolos Armaganidis, MD, PhD · National and Kapodistrian University of Athens

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-12
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03195543 on ClinicalTrials.gov