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Development of a Skin Test for the Na-ASP-2 Hookworm Antigen

NCT00603889 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2012-02-23

Study results available
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Summary

Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. In a clinical study in previously hookworm-infected adults in Brazil, this protein induced urticarial reactions (rash) in a subset of volunteers. This study will evaluate solutions of varying concentrations of the protein in both a skin prick-puncture and intradermal test that will eventually be used to screen volunteers living in hookworm endemic areas who are being considered as potential participants in vaccine trials, to reduce the potential of inducing allergic reactions in those vaccinated with the Na-ASP-2 Hookworm Vaccine.

Conditions

  • Hookworm Infection
  • Allergy

Interventions

BIOLOGICAL

Na-ASP-2 Skin Test Reagent

Na-ASP-2 Hookworm Skin Test Reagent, 1-1000 mcg/mL solution

Sponsors & Collaborators

  • Albert B. Sabin Vaccine Institute

    lead OTHER

Principal Investigators

  • David Parenti, MD · GWUMC Medical Faculty Associates

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-03-31
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00603889 on ClinicalTrials.gov