Safety and Efficacy of PF-04217329 in Patients With Glaucoma or Elevated Eye Pressure.

Summary

To evaluate the safety and efficacy of PF-04217329.

Conditions

• Primary Open-Angle Glaucoma
• Ocular Hypertension

Interventions

DRUG

PF-04217329 - Lowest Dose

1 drop of lowest dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Low Dose

1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Middle Dose

1 drop of middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Middle Dose

1 drop of high middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Dose

1 drop of high dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-4217329 - Highest Dose

1 drop of highest dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Vehicle

1 drop of PF-04217329 vehicle, once a day, per dosed eye for duration of study.

DRUG

Latanoprost Vehicle

1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Low Dose

Five minutes after latanoprost vehicle, 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost Vehicle

1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Middle Dose

Five minutes after latanoprost vehicle, 1 drop of middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost Vehicle

1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Dose

Five minutes after latanoprost vehicle, 1 drop of high dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Low Dose

Five minutes after latanoprost 0.005%, 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Middle Dose

Five minutes after latanoprost 0.005%, 1 drop middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Dose

Five minutes after latanoprost 0.005%, 1 drop high dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Vehicle

Five minutes after latanoprost 0.005%, 1 drop of PF-04217329 vehicle, once a day, per dosed eye for duration of study.

Sponsors & Collaborators

• Pfizer

  lead INDUSTRY

Principal Investigators

• Pfizer CT.gov Call Center · Pfizer

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-12-11

Primary Completion

2009-06-26

Completion

2009-06-26

Countries

• United States

Study Locations