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Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK

NCT00569881 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 22

Last updated 2007-12-10

No results posted yet for this study

Summary

The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target tissue, and be safe and not toxic to any layer of the healing cornea, especially the epithelium. Several studies have investigated the toxicity of the fourth generation fluoroquinolones on the corneal epithelium and studies have demonstrated that gatifloxacin is less deleterious to the healing cornea than moxifloxacin. Most of these studies, however, have been conducted in animals. This was a retrospective chart review.

Conditions

  • Corneal Epithelial Wound Healing

Interventions

DRUG

gatifloxacin and moxifloxacin

Comparison of wound healing between drugs

Sponsors & Collaborators

  • Donnenfeld, Eric, M.D.

    lead INDIV

Principal Investigators

  • Eric Donnenfeld, MD · OCLI

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-01-31
Completion
2007-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00569881 on ClinicalTrials.gov