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Observational Endothelin and Markers of Cellular Apoptosis In CSF Head Injury

NCT00498498 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 51

Last updated 2011-11-16

No results posted yet for this study

Summary

The goal of this study is to answer the following questions:

* What is the time course of the expected changes in endothelin levels during the first two weeks after injury and how does this relate to outcome?
* What is the relation between endothelin levels (big ET-1 and ET-1) in plasma and cerebrospinal fluid and type of injury, from CT scans and GCS?
* What is the relation between endothelin levels (big ET-1 and ET-1) in plasma and cerebrospinal fluid and outcome measurements like GOSE, ICP and CT scans?
* What is the relation between neurohormones related to the neutral endopeptidase (NEP) (ANP, BNP and cGMP) in plasma and cerebrospinal fluid and type of injury, from CT scans and GCS?
* What is the relation between endothelin levels (big ET-1 and ET-1) in plasma and cerebrospinal fluid and markers for apoptosis?

Conditions

  • Cerebrovascular Trauma
  • Neurohormones
  • Cellular Apoptosis
  • Endothelin System

Sponsors & Collaborators

  • Solvay Pharmaceuticals

    collaborator INDUSTRY

  • Virginia Commonwealth University

    lead OTHER

Principal Investigators

  • John Ward, MD · Virginia Commonwealth University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-07-31
Primary Completion
2009-06-30
Completion
2009-12-31

Countries

  • United States
  • Germany
  • Italy
  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00498498 on ClinicalTrials.gov