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DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.

NCT00478933 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1223

Last updated 2025-07-02

Study results available
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Summary

To prospectively evaluate if the analysis of genetic polymorphisms can be used to identify patients at risk of ventricular tachycardia.

To evaluate the influence of ICD-based diagnostic information on the long term treatment and management of primary prevention ICD-patients.

Conditions

  • Death, Sudden, Cardiac
  • Ventricular Fibrillation
  • Tachycardia
  • Atrial Fibrillation
  • Sick Sinus Syndrome

Interventions

DEVICE

Defibrillator, Dual Chamber ; Implantable

Patient must wear a dual chamber ICD to remain in study. Can be enrolled 10 days prior to implant. Is excluded if device type changes.

PROCEDURE

Blood sampling

Blood sampling

Sponsors & Collaborators

  • Medtronic Cardiac Rhythm and Heart Failure

    lead INDUSTRY

Principal Investigators

  • Domenico Corrado, MD · University of Padova, Italy

  • Heiner Wieneke, MD · Universitätsklinikum Essen, Germany

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-02-28
Primary Completion
2012-07-31
Completion
2012-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00478933 on ClinicalTrials.gov