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Regulatory T Cells in COPD

NCT00452764 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2007-11-08

No results posted yet for this study

Summary

Lymphoid follicles, consisting of T-and B cells, are involved in the chronic inflammatory response in COPD. Foxp3 positive regulatory T cells (Tregs) are present in these follicles and may be involved in the suppression of this chronic inflammatory response.

We hypothesise that a dysfunction of Tregs underlies the development of the inflammatory response in COPD. This could be either due to a decreased presence of Tregs in COPD, or to an altered function of Tregs possibly caused by a decreased HO-1 expression and/or an altered TGFβ regulation.

Conditions

Interventions

BEHAVIORAL

Withdrawal of medication

Sponsors & Collaborators

  • Groningen Research Institute for Asthma and COPD

    lead OTHER

Principal Investigators

  • Huib AM Kerstjens, MD, PhD · UMCG, department of pulmonary diseases

Eligibility

Min Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-01-31
Completion
2007-11-30

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00452764 on ClinicalTrials.gov