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Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

NCT00449306 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2019-07-05

No results posted yet for this study

Summary

Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives:

"1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression.

"2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques.

"3" Explore the potential role of infection in atherogenesis.

Conditions

Sponsors & Collaborators

  • University Hospital Goettingen

    collaborator OTHER

  • Carmel Medical Center

    collaborator OTHER

  • CVPath Institute Inc.

    collaborator OTHER

  • Sheba Medical Center

    lead OTHER_GOV

Principal Investigators

  • Jacob Schneiderman, MD · Department of Vascular Surgery, Sheba Medical Center, Tel Hashomer

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-03-31
Primary Completion
2021-07-31
Completion
2021-07-31

Countries

  • Israel

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00449306 on ClinicalTrials.gov