Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease

Summary

Recent data show that pulmonary hypertension (PH), defined by a tricuspid regurgitation jet (TRJ) velocity \> or equal at 2.5m/s on Doppler echocardiography, is present in about 30% of adults with sickle cell disease (SCD) and is associated with poor prognosis. However in SCD the occurrence of PH (defined by mean pulmonary arterial pressure (mPAP)\> or equal at 25 mmHg) is related to at least 3 mechanisms: PH due to hyperkinetic state with high cardiac output (CO) but normal pulmonary vascular resistance (PVR \<160 dynes), or postcapillary PH (pulmonary capillary wedge pressure PCWP \>15 mmHg), or precapillary pulmonary arterial hypertension (PAH) defined by mPAP \> or equal at 25 mmHg, PCWP\< or equal at 15 mmHg and PVR \> or equal at 160 dynes.The aim of this study is to evaluate in a French population of adults with sickle cell disease the characteristics, prevalence and prognosis of pulmonary hypertension.

Conditions

• Sickle Cell Disease

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Gerald SIMONNEAU, MD · Hôpital Antoine Béclère, CLAMART

• Frederic Galacteros, MD · Hôpital Henri Mondor, Creteil

• Serge ADNOT, MD · Hôpital Henri Mondor, CRETEIL

• Bernard MAITRE, MD · Hopital Henri Mondor, CRETEIL

• Marc HUMBERT, MD · Hôpîtal Antoine Béclere, CLAMART

• Robert GIROT, MD · Hôpital Tenon, PARIS

• François LIONNET, MD · Hôpital TENON, PARIS

• Françoise DRISS, MD · Hôpital Bicêtre, KREMLIN BICETRE

• Olivier LAMBOTTE, MD · Hôpital Bicêtre, KREMLIN BICETRE

• Jocelyn INAMO, MD · CHU Fort de France

• Gylna LOKO, MD · CHU Fort de France

• Olivier SITBON, MD · Hôpital Antoine Béclère, CLAMART

• Xavier Jaïs, MD · Hôpital Antoine Béclère, CLAMART

• Anoosha Habibi, MD · Hôpital Henri Mondor, CRETEIL

• Dora Bachir, MD · Hôpital Henri Mondor, CRETEIL

• Laurent SAVALE, MD · Hopital Henri Mondor, CRETEIL

• Saadia Eddahibi, MD · Hôpital Henri Mondor, CRETEIL

• Gilles Garcia, MD · Hopital Antoine Béclère, CLAMART

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-02-28

Primary Completion

2009-03-31

Completion

2012-12-31

Countries

• France

Study Locations