Pazopanib Plus Lapatinib Compared to Lapatinib Alone and Pazopanib Alone In Subjects With Metastatic Cervical Cancer
NCT00430781 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 228
Last updated 2015-05-08
Summary
This study is being conducted to compare the efficacy and safety of pazopanib in combination with lapatinib with that of lapatinib alone or pazopanib alone in subjects with metastatic cervical cancer
Conditions
- Neoplasms, Uterine Cervix
- Metastatic Cervical Cancer
Interventions
- DRUG
-
pazopanib (GW786034)
- DRUG
-
lapatinib (GW572016)
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
GSK Clinical Trials · GlaxoSmithKline
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-11-30
- Primary Completion
- 2008-07-31
- Completion
- 2011-07-31
Countries
- United States
- Argentina
- Belgium
- Canada
- Estonia
- France
- Germany
- India
- Ireland
- Italy
- Mexico
- Spain
- Thailand
Study Locations
More Related Trials
-
Lapatinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer
NCT00098631 ·Status: COMPLETED ·Phase: PHASE2
-
A Multicenter, Prospective, Randomized Trial of Adjuvant Chemotherapy for Early-Stage Cervical Cancer Patients
NCT01755897 ·Status: COMPLETED ·Phase: NA
-
Topotecan and Paclitaxel in Treating Patients With Recurrent or Metastatic Cancer of the Cervix
NCT00003065 ·Status: COMPLETED ·Phase: PHASE2
-
Pazopanib in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
NCT01377298 ·Status: UNKNOWN ·Phase: PHASE2
-
Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck
NCT05172258 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma
NCT01438554 ·Status: COMPLETED ·Phase: PHASE1
-
Pembrolizumab and Olaparib in Cervical Cancer Patients
NCT04483544 ·Status: TERMINATED ·Phase: PHASE2
-
Paclitaxel, Topotecan, and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
NCT00276796 ·Status: COMPLETED ·Phase: PHASE2
-
Study on Paclitaxel Plus Topotecan in Comparison With Topotecan Plus Cisplatin in Recurrent or Persistent Cervical Carcinoma
NCT01405235 ·Status: UNKNOWN ·Phase: PHASE3
-
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
NCT07061977 ·Status: RECRUITING ·Phase: PHASE3
-
Niraparib Combined With Brivanib or Toripalimab in Patients With Cervical Cancer
NCT04395612 ·Status: UNKNOWN ·Phase: PHASE2
-
Liposomal Doxorubicin in Treating Patients With Persistent or Recurrent Cancer of the Cervix
NCT00030472 ·Status: TERMINATED ·Phase: PHASE2
-
Patritumab With Cetuximab and a Platinum Containing Therapy for Patients With Head and Neck Cancer
NCT02350712 ·Status: COMPLETED ·Phase: PHASE1
-
Platinum Chemotherapy Plus Paclitaxel With Bevacizumab and Atezolizumab in Metastatic Carcinoma of the Cervix
NCT03556839 ·Status: COMPLETED ·Phase: PHASE3
-
First-line Chemotherapy for Recurrent Cervical Cancer
NCT04188847 ·Status: COMPLETED ·Phase: PHASE2
-
Pazopanib Plus Cetuximab for Incurable Head and Neck Squamous Cell Carcinoma (HNSCC)
NCT01716416 ·Status: COMPLETED ·Phase: PHASE1
-
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
NCT07216703 ·Status: RECRUITING ·Phase: PHASE3
-
Trial of TP Versus TC Regimens for Stage IVb, Persistent, or Recurrent Cervical Cancer (JCOG0505, CC-TPTC-P3)
NCT00295789 ·Status: COMPLETED ·Phase: PHASE3
-
QL1706 Plus Neoadjuvant Chemotherapy Followed by Type I Hysterectomy for Locally Advanced Cervical Cancer
NCT07205497 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Lapatinib Ditosylate in Treating Patients With Metastatic or Recurrent Head and Neck Cancer
NCT00114283 ·Status: COMPLETED ·Phase: PHASE2
-
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
NCT06997094 ·Status: RECRUITING ·Phase: PHASE1
-
Capecitabine in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
NCT00016926 ·Status: COMPLETED ·Phase: PHASE2
-
Capecitabine in Treating Patients With Persistent or Recurrent Cervical Cancer
NCT00039442 ·Status: COMPLETED ·Phase: PHASE2
-
Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck
NCT01044433 ·Status: COMPLETED ·Phase: PHASE2
-
QL706 + Chemo ± Bevacizumab in Anti-PD-(L)1-Resistant R/M Cervical Cancer
NCT07186868 ·Status: NOT_YET_RECRUITING