Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma
NCT01438554 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 89
Last updated 2018-08-29
Summary
The purpose of this study is to determine the safety and toxicity of the combination of pazopanib and GSK1120212 in patients with solid tumors and identify the maximum tolerated dose (MTD) of this combination for phase II study.
Conditions
- Solid Tumors
- Thyroid Cancer
- Soft-tissue Sarcoma
- Cholangiocarcinoma
Interventions
- DRUG
-
Pazopanib
- DRUG
-
GSK1120212
Sponsors & Collaborators
-
National Comprehensive Cancer Network
collaborator NETWORK - collaborator INDUSTRY
-
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
lead OTHER
Principal Investigators
-
Nilo Azad, MD · Johns Hopkins University
Study Design
- Allocation
- NA
- Purpose
- OTHER
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2011-10-31
- Primary Completion
- 2016-04-30
- Completion
- 2018-08-31
Countries
- United States
Study Locations
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