Metronomic Chemotherapy by Cyclophosphamide Versus Megestrol in Palliative Cancer
NCT00420563 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 88
Last updated 2026-03-16
Summary
The scope of the trial is to assess the free progression rate at 2 months for each group of patients.
Conditions
Interventions
- DRUG
-
MEGESTROL
320 mg/day, per os, 2 pills of 160 mg one time, nonstop until disease progression or toxicity or patient decision
- DRUG
-
50 mg x 2 /day , per os, nonstop until disease progression or toxicity or patient decision
Sponsors & Collaborators
-
Centre Oscar Lambret
lead OTHER
Principal Investigators
-
PENEL Nicolas, MD · Centre Oscar Lambret
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2009-09-25
- Primary Completion
- 2011-01-19
- Completion
- 2011-01-19
Countries
- France
Study Locations
More Related Trials
-
Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors
NCT00470366 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine in Treating Patients With Metastatic Cancer of Unknown Primary
NCT00357630 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Trial of Pemetrexed-Based Induction Chemotherapy Followed by Concomitant Chemoradiotherapy in Previously Irradiated Head and Neck Cancer Patients
NCT01172470 ·Status: COMPLETED ·Phase: PHASE2
-
Pemetrexed Disodium Plus Gemcitabine in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT00022646 ·Status: COMPLETED ·Phase: PHASE2
-
Pemetrexed Plus Cisplatin for Brain Metastasis of Advanced Non - Small Cell Lung Cancer (NSCLC)
NCT00744900 ·Status: COMPLETED ·Phase: PHASE2
-
17-N-Allylamino-17-Demethoxygeldanamycin and Paclitaxel in Treating Patients With Metastatic or Unresectable Solid Tumor
NCT00087217 ·Status: COMPLETED ·Phase: PHASE1
-
An Effective and Compliance Regimen of Paclitaxel Plus Cisplatin to Treat Metastatic Breast Cancer
NCT00270569 ·Status: UNKNOWN ·Phase: PHASE2
-
MILES-4: Study Comparing Gemcitabine and Pemetrexed, With or Without Cisplatin, in Patients With Nonsquamous Lung Cancer
NCT01656551 ·Status: UNKNOWN ·Phase: PHASE3
-
Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors
NCT00551122 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors
NCT00003518 ·Status: COMPLETED ·Phase: PHASE2
-
Pemetrexed Plus Gemcitabine for Patients With Locally Advanced or Metastatic NSCLC Who Have Not Had Previous Chemotherapy.
NCT00061464 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study of Oxaliplatine-Paclitaxel in Patients With Metastatic Germ Cell Tumor Refractory to Cisplatin
NCT00611962 ·Status: COMPLETED ·Phase: PHASE2
-
A Study for Patients With Head and Neck Cancer
NCT00415194 ·Status: COMPLETED ·Phase: PHASE3
-
Alimta and Gemcitabine in Non-Small Cell Lung Cancer
NCT00434135 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of RO6927005 Either As Monotherapy (Part A) or in Combination With Gemcitabine and Nab-Paclitaxel (Part B) to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Clinical Activity in Patients With Mesothelin-positive Metastatic and/or Locally Advanced Malignant Solid Tumors
NCT02317419 ·Status: TERMINATED ·Phase: PHASE1
-
A Study to Determine the Bioequivalence of Oraxol in Cancer Patients Treated With Intravenous Paclitaxel
NCT04035473 ·Status: COMPLETED ·Phase: PHASE1
-
Carboplatin and Gemcitabine in Treating Patients With Locally Advanced or Metastatic Breast Cancer
NCT00470249 ·Status: TERMINATED ·Phase: PHASE2
-
Pemetrexed Plus Gemcitabine as Front-Line Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer: A Clinical Trial
NCT00061451 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00004242 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers
NCT01104714 ·Status: COMPLETED
-
Trial of Pemetrexed or Pemetrexed With Gemcitabine for Patients With Advanced Lung Cancer Who Are Not Eligible for Platinum-Based Chemotherapy and Have Not Previously Been Treated With Chemotherapy
NCT00489983 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma
NCT03656536 ·Status: TERMINATED ·Phase: PHASE3
-
Phase II Pilot Study Assessing Efficacy of a Cisplatin - Métronomic Cyclophosphamide Treatment in Patients With Stade IV Triple Negative Breast Cancer Secondary Resistant to Anthracyclines and Taxanes
NCT01910844 ·Status: TERMINATED ·Phase: PHASE2
-
Open-label, Multicenter, Randomized Phase II Trial of Treatment With Cisplatin and Pemetrexed or Cisplatin and Oral Vinorelbine in Chemotherapy Naïve Patients Affected by Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer With High Thymidylate Synthase Expression
NCT02919462 ·Status: TERMINATED ·Phase: PHASE2
-
Oxaliplatin and Paclitaxel in Treating Patients With Metastatic or Unresectable Cancer
NCT00004173 ·Status: UNKNOWN ·Phase: PHASE1