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Oxidative Stress and Hemodialysis Access Failure

NCT00410449 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2015-10-06

No results posted yet for this study

Summary

Complications of hemodialysis access are the most frequent single reason for hospitalization among patients with End Stage Renal Disease (ESRD). Uremia, and particularly uremia in patients with diabetes, is a state of increased oxidative stress. The central hypothesis to be tested by this project is that oxidative stress is a major (and modifiable) trigger for vascular access complications. We hope to slow or reduce rates of stenosis, thrombosis and access complications by giving Vitamin E supplementation to patients being treated by hemodialysis.

Conditions

Interventions

DRUG

Alpha tocopherol

Sponsors & Collaborators

  • Leonard B Rosenberg Renal Research Foundation

    collaborator UNKNOWN

  • National Institute of Environmental Health Sciences (NIEHS)

    lead NIH

Principal Investigators

  • Miriam F Weiss, M.D. · Case Western Reserve University

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-05-31
Completion
2004-05-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00410449 on ClinicalTrials.gov