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The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease

NCT00410007 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2018-03-20

No results posted yet for this study

Summary

The aim of the study is to test the following hypotheses:

1. that the function and/or regulation of AQP2 and /or ENaC in the principal cells is abnormal in autosomal dominant polycystic kidney disease.
2. if an abnormal function of the principal cells is present in autosomal dominant polycystic kidney disease, this will become more pronounced at high and low sodium intake.

Conditions

  • Polycystic Kidney, Autosomal Dominant

Interventions

BEHAVIORAL

High Sodium Diet

250-350 mmol

BEHAVIORAL

Low Sodium Diet

25-35 mmol

BEHAVIORAL

Hypertonic saline infusion

7 ml/ kg of 3% saline were given over 30 minutes.

Sponsors & Collaborators

  • Carolina Cannillo

    lead OTHER

Principal Investigators

  • Erling B. Pedersen, Professor · Department of Medical Research, Holstebro Hospital, Denmark

  • Carolina C. Graffe, MD · Department of Medical Research, Holstebro Hospital, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-10-31
Primary Completion
2010-10-31
Completion
2011-11-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00410007 on ClinicalTrials.gov