Effects of Coenzyme Q10 in Progressive Supranuclear Palsy (PSP)
NCT00382824 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 61
Last updated 2019-08-01
Summary
The clinical syndrome of PSP responds poorly to all available forms of therapy used in Parkinson's Disease (PD). Currently, no effective treatment exists. Coenzyme Q10 in high doses has been shown to be a beneficial therapy in PD and might possibly be a beneficial therapy for PSP. This study will compare the efficacy, safety and tolerability of Coenzyme Q10 versus placebo in patients with atypical parkinsonian syndrome, progressive supranuclear palsy (PSP).
Conditions
Interventions
- DIETARY_SUPPLEMENT
-
Coenzyme Q10
active drug
- OTHER
-
Placebo
Placebo
Sponsors & Collaborators
-
Lahey Clinic
lead OTHER
Principal Investigators
-
Diana Apetauerova, MD · Lahey Clinic
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 30 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-09-30
- Primary Completion
- 2013-09-30
- Completion
- 2015-01-31
Countries
- United States
Study Locations
More Related Trials
-
NINDS Parkinson's Disease Neuroprotection Trial of CoQ10 and GPI 1485
NCT00076492 ·Status: COMPLETED ·Phase: PHASE2
-
Ubiquinol in Parkinson's Disease: Safety, Tolerability, and Effects Upon Oxidative Damage and Mitochondrial Biomarkers
NCT03061513 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)
NCT04993768 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Subjects With Progressive Supranuclear Palsy (PSP)
NCT02985879 ·Status: TERMINATED ·Phase: PHASE2
-
Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy
NCT02494024 ·Status: COMPLETED ·Phase: PHASE1
-
RT001 in Patients With Progressive Supranuclear Palsy (PSP) PROGRESSIVE SUPRANUCLEAR PALSY
NCT04937530 ·Status: UNKNOWN ·Phase: PHASE2
-
In-Home Care for Patients With PSP and Related Disorders
NCT03552484 ·Status: COMPLETED ·Phase: NA
-
Placebo Controlled Study of Preladenant in Participants With Moderate to Severe Parkinson's Disease (P07037)
NCT01227265 ·Status: COMPLETED ·Phase: PHASE3
-
The Progressive Supranuclear Palsy Clinical Trial Platform
NCT07173803 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Essential Amino Acids and Parkinsons Disease
NCT06604065 ·Status: WITHDRAWN ·Phase: PHASE1
-
Coenzyme Q10 in Huntington's Disease (HD)
NCT00608881 ·Status: TERMINATED ·Phase: PHASE3
-
A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of UCB0022 in Study Participants With Advanced Parkinson's Disease
NCT06055985 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy Study for Treatment of Dementia in Progressive Supranuclear Palsy
NCT00522015 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
NCT07174310 ·Status: RECRUITING ·Phase: PHASE3
-
The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease
NCT01676103 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Multicenter Study of Rasagiline in Parkinson's Disease Patients Using Levodopa and Experiencing Motor Fluctuations
NCT00203034 ·Status: COMPLETED ·Phase: PHASE3
-
Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy (Depakine)
NCT00385710 ·Status: COMPLETED ·Phase: PHASE2
-
Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease
NCT01723228 ·Status: COMPLETED ·Phase: PHASE4
-
The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen B: LM11A-31
NCT07264283 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Phase 2 Study to Assess the Effects of SUL-238 on High Energy Phosphates With ³¹P-MRS in Patients With Early, Untreated Parkinson's Disease
NCT07322887 ·Status: RECRUITING ·Phase: PHASE2
-
The Progressive Supranuclear Palsy Clinical Trial Platform - Regimen A: AADvac1
NCT07217665 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Intranasal Glutathione in Parkinson's Disease
NCT01398748 ·Status: COMPLETED ·Phase: PHASE1
-
Safety Study of TPI-287 to Treat CBS and PSP
NCT02133846 ·Status: COMPLETED ·Phase: PHASE1
-
To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications
NCT06553027 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Bioavailability of Ubiquinol in Huntington Disease
NCT00980694 ·Status: COMPLETED ·Phase: PHASE1