Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure
NCT00359697 · Status: UNKNOWN · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 50
Last updated 2014-11-06
Summary
The overall purpose of this study is to compare the effects of mannitol and hypertonic saline on patients with increased intracranial pressure. The hypothesis being tested is that hypertonic saline is more effective in controlling increased intracranial pressure than mannitol.
Conditions
- Increased Intracranial Pressure
Interventions
- DRUG
-
Hypertonic Saline, Mannitol
Sponsors & Collaborators
-
Thomas Jefferson University
lead OTHER
Principal Investigators
-
Robert H Rosenwasser, MD · Thomas Jefferson University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
More Related Trials
-
Osmotic Therapy for Treatment of Intracranial Hypertension for Traumatic Brain Injury
NCT01215019 ·Status: WITHDRAWN ·Phase: NA
-
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
NCT01605357 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring
NCT00795587 ·Status: TERMINATED ·Phase: PHASE4
-
Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension
NCT03409237 ·Status: WITHDRAWN
-
Sodium-Lactate and Traumatic Brain Injury
NCT00319345 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
Sodium Lactate Versus Hypertonic Saline Solution in the Treatment of Intracranial Hypertensive Episodes in Severe Brain Injured Patients
NCT06110429 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation
NCT03573999 ·Status: COMPLETED ·Phase: PHASE4
-
Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy
NCT02037815 ·Status: COMPLETED ·Phase: PHASE4
-
Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache
NCT02760862 ·Status: COMPLETED ·Phase: PHASE4
-
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
NCT05858060 ·Status: RECRUITING
-
The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours
NCT03444519 ·Status: COMPLETED ·Phase: NA
-
ICP Versus Intracranial Compliance Guided Management in SAH
NCT00248690 ·Status: COMPLETED ·Phase: NA
-
Early Induced Hypernatremia for the Prevention and Management of Brain Edema
NCT02798601 ·Status: WITHDRAWN ·Phase: NA
-
A Low ChloridE hyperTonic Solution for Brain Edema
NCT03204955 ·Status: COMPLETED ·Phase: PHASE1
-
Point of Care Optic Nerve Sheath Ultrasound to Assess Intracranial Pressure
NCT04686344 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.
NCT03828032 ·Status: UNKNOWN ·Phase: NA
-
Preventive Sodium Lactate and Traumatic Brain Injury
NCT00995683 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Mannitol Brain Relaxation Effect
NCT02168075 ·Status: UNKNOWN ·Phase: NA
-
Hypertonic Saline as Therapy for Pediatric Concussion
NCT01612494 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Intracranial Pressure in Experimental Models of Headache
NCT01288781 ·Status: COMPLETED ·Phase: NA
-
Hypertonic Saline for Mild TBI in Pediatric Patients
NCT07060105 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury
NCT00810940 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
NCT02432157 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Idiopathic Intracranial Hypertension Treatment Trial
NCT01003639 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
New Reference Values for Intracranial Pressure
NCT03594136 ·Status: COMPLETED ·Phase: NA