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Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis

NCT00355576 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 86

Last updated 2011-02-01

No results posted yet for this study

Summary

The objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS.

Conditions

Interventions

DRUG

Celecoxib

Celecoxib 400 mg BID with creatine 10 g BID if randomized to the Celecoxib + Creatine study arm.

DRUG

Creatine

10 g BID for either study arm

DRUG

Minocycline

Minocycline 100 mg BID with creatine 10 g BID if randomized to the Minocycline + Creatine study arm

Sponsors & Collaborators

Principal Investigators

  • Paul H Gordon, MD · Columbia University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-07-31
Completion
2007-05-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00355576 on ClinicalTrials.gov