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Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease

NCT00305175 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 260

Last updated 2020-07-28

No results posted yet for this study

Summary

The primary objectives of this prospective, observational study are (1) to describe the long-term cellular, molecular, and clinical effects of hydroxyurea therapy in sickle cell disease, and (2) to perform hydroxyurea pharmacokinetics studies.

This study will follow sickle cell patients being treated with hydroxyurea for a long period of time to evaluate the long-term cellular and molecular effects of the drug on the patients' body. This study will consist of two patient groups. One group will be made up of patients who have received hydroxyurea therapy before entering the study. The second group will be made up of patients who have not received hydroxyurea before study entry.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Jeremie Estepp, MD · St. Jude Children's Research Hospital

Eligibility

Max Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-03-03
Primary Completion
2015-04-23
Completion
2015-04-23

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00305175 on ClinicalTrials.gov