Pemetrexed Disodium in Treating Patients With Recurrent Malignant Gliomas, Primary CNS Lymphoma, or Brain Metastases
NCT00276783 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 31
Last updated 2020-03-05
Summary
RATIONALE: Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
PURPOSE: This phase II trial is studying how well pemetrexed disodium works in treating patients with recurrent malignant gliomas, primary CNS lymphoma, or brain metastases.
Conditions
Interventions
- DRUG
-
pemetrexed
Administered intravenously at a dose of 900 mg/m2 every 21 days until disease progression.
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH - lead OTHER
Principal Investigators
-
Jeffrey J. Raizer, MD · Robert H. Lurie Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 120 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2005-11-30
- Primary Completion
- 2022-12-31
- Completion
- 2022-12-31
Countries
- United States
Study Locations
More Related Trials
-
Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma
NCT00087061 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Efficacy and Safety Evaluation of Percutaneous Ommaya Capsule Injection of Autologous Bi-dimensional Specific T Cells in the Treatment of Glioma and in Combination With Pemetrexed in the Treatment of Brain/Meningeal Metastases
NCT05459441 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis
NCT05305885 ·Status: UNKNOWN ·Phase: NA
-
AZD2171 in Treating Patients With Recurrent Glioblastoma Multiforme
NCT00305656 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations
NCT05267106 ·Status: TERMINATED ·Phase: PHASE2
-
Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors
NCT03507244 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Pembrolizumab in Treating Patients With Recurrent Glioblastoma
NCT02337686 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain
NCT01904123 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Therapy for the Treatment of Diffuse Midline Gliomas
NCT05009992 ·Status: RECRUITING ·Phase: PHASE2
-
Bortezomib in Treating Patients With Recurrent Glioma
NCT00006773 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas
NCT00045708 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine
NCT00074607 ·Status: TERMINATED ·Phase: PHASE1
-
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
NCT02359565 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma
NCT00002676 ·Status: COMPLETED ·Phase: PHASE2
-
Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been Removed By Surgery
NCT00275067 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Bendamustine Hydrochloride in Treating Patients With Recurrent or Progressive Anaplastic Glioma
NCT00823797 ·Status: COMPLETED ·Phase: PHASE2
-
Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
NCT00293475 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma
NCT00979862 ·Status: COMPLETED ·Phase: PHASE1
-
[90Y]Y-PTT Endoradiotherapy in CNS Lymphoma Patients
NCT06132737 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Phase II Trial of Combined Modality Treatment in Primary Central Nervous System Lymphoma
NCT00210314 ·Status: COMPLETED ·Phase: PHASE2
-
Combination of Alpelisib and Trametinib in Progressive Refractory Meningiomas
NCT03631953 ·Status: RECRUITING ·Phase: PHASE1
-
Therapeutic Strategies in Patients With Non-squamous Non-small Cell Lung Cancer With Brain Metastases
NCT02162537 ·Status: TERMINATED ·Phase: PHASE3
-
Pyrazoloacridine Plus Carboplatin in Treating Patients With Recurrent Glioma
NCT00005976 ·Status: COMPLETED ·Phase: PHASE2
-
Methotrexate and Thiotepa in Treating Patients With Newly Diagnosed Primary CNS Lymphoma
NCT00045539 ·Status: COMPLETED ·Phase: PHASE2
-
Irinotecan in Treating Patients With Recurrent Glioma
NCT00003134 ·Status: COMPLETED ·Phase: PHASE2